Brain volume data in Brazilian patients with opticspinal and conventional multiple sclerosis

Abstract

Opticspinal Multiple Sclerosis (OSMS) is a MS phenotype described in Asian population characterized nowdays by recurrent optic neuritis and transverse myelitis small spinal cord lesions and AQP4 – Ab negative. The objective of the study was to analyze and compare Brain MRI by MSmetrix reports in OSMS and Conventional MS patients (CMS) from Rio de Janeiro where the majority of the population is Afro descendent. 58 MS patients were scanned on HDxt GE 1,5 T. For each scanner a 3D T1 and 3D FLAIR were acquired and analysed blinded in icometrix platform. Data on whole brain volume (WBV), gray matter volume (GMV), total load volume 3DT1, 3DFLAIR image and white matter lesions segmentation were analyzed and compared blinded between OSMS and RRMS groups. OSMS and CMS groups had similar demographic and long term disability (Median EDSS <1.5). OSMS had a longer time of disease (19 versus 13 years) . As shown at Table 1, the total load volume 3DFLAIR and periventricular and deep white matter load lesions were significantly higher in CMS than OSMS. Periventricular lesions were identified in 100% of the participants but infratentorial lesions ocurred in 50% of OSMS and 27,9 of CMS and deep WM lesions in 100% of CMS and 30% of OSMS. Cerebral atrophy measured by the WBV and GMV not differed between the groups, however, the 3DT1 volume was significantly higher in CMS. MSmetrix records showed different T2 and T1 patterns of Brain lesions between OSMS and CMS.