Abstract

Regional brain volumes have been compared at initial MRI scans and their change over time in 152 medicated and previously unmedicated male and female patients (age range, 5-18 years) with attention-deficit/hyperactivity disorder (ADHD) and 139 age- and sex-matched healthy controls.

Highlights

  • Vitamin A levels were measured in the cerebrospinal fluid of a total of 78 patients having idiopathic intracranial hypertension (IIH;n=20), elevated pressure of other causes (E-ICP;n=19), and normal pressure (N-ICP;n=39), in a study at the University of Utah, Salt Lake City, UT

  • Serum retinolbinding protein (RBP) and retinol are elevated in some patients with IIH (Jacobson DM, Berg R, Wall M, et al Neurology 1999;53:1114-1118)

  • Regional brain volumes have been compared at initial MRI scans and their change over time in 152 medicated and previously unmedicated male and female patients with attention-deficit/hyperactivity disorder (ADHD) and 139 age- and sex-matched healthy controls

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Summary

Introduction

Vitamin A levels were measured in the cerebrospinal fluid of a total of 78 patients having idiopathic intracranial hypertension (IIH;n=20), elevated pressure of other causes (E-ICP;n=19), and normal pressure (N-ICP;n=39), in a study at the University of Utah, Salt Lake City, UT. Higher CSF vitamin A levels found in some patients with IIH were significantly correlated (p=0.036) when compared with control E-ICP and IIH patients. Some patients with idiopathic intracranial hypertension have significantly higher levels of vitamin A in the CSF than patients with normal pressure or those with increased pressure due to other causes.

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