Abstract
Halogenated products of D-glucal were obtained on direct addition of halogens (36Cl and82Br) to D-glucal, which is a class of unsaturated sugar derivatives and had been synthesized from D-glucose. Brain uptake of the halogenated products was found to be greater than those of 2-deoxy-D-glucose and D-glucose. The halogenation reaction is sufficiently rapid and usable activity from D-glucal dihalides is twice as much as those from equal moles of18F-2-deoxy-2-fluoro-D-glucose and18F-3-deoxy-3-fluoro-D-glucose. D-Glucal can be readily available for months without any detectable chemical alteration.
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