Abstract
In humans, gliomas constitute about 30-45% of all intracranial tumours. Conventional therapy for high-grade gliomas consists of surgery that is followed by radiation therapy and/or by chemotherapy. The life expectancy of patients with glioblastoma is less than one year from the time of diagnosis’, therefore development of new therapeutic approaches is necessary. Animal models have demonstrated the efficacy of cytokine gene therapy of melanomas using autologous cancer cells producing various cytokines2’3. We decided to study the therapeutic effect of cytokine expressing cancer cell vaccines for the treatment of high-grade gliomas.
Published Version
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