Brain tumor imaging of rat fresh tissue using terahertz spectroscopy.

Sayuri Yamaguchi,Toshihiko Ouchi,Takeaki Itsuji,Yasuko Fukushi,Seiji Yamamoto,Oichi Kubota

doi:10.1038/srep30124

Sayuri Yamaguchi, Toshihiko Ouchi + Show 4 more

Open Access

https://doi.org/10.1038/srep30124

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Abstract

Highlights

Tumor imaging by terahertz spectroscopy of fresh tissue without dye is demonstrated using samples from a rat glioma model
We have reported the possibility of glioma detection from the complex refractive index obtained by THz spectroscopy of rat fresh tissue and of applying principal component analysis during statistical analysis to distinguish normal and tumor tissues[20]
An example of the refractive index spectra and absorption coefficient spectra of normal and tumor regions of fresh tissues from rat brain are shown in Fig. 1(a,b), respectively

Summary

Introduction

Tumor imaging by terahertz spectroscopy of fresh tissue without dye is demonstrated using samples from a rat glioma model. The complex refractive index spectrum obtained by a reflection terahertz time-domain spectroscopy system can discriminate between normal and tumor tissues. The detection of gliomas using THz waves could overcome problems of above mentioned MRI and fluorescence imaging during surgery and was recently described by Son et al.[16,17] They used the peak-to-peak reflection ratio of a THz signal to distinguish normal and tumor tissues and to generate THz images of glioma in fresh tissue from rats. We have reported the possibility of glioma detection from the complex refractive index obtained by THz spectroscopy of rat fresh tissue and of applying principal component analysis during statistical analysis to distinguish normal and tumor tissues[20]. The purpose of this study was to investigate the possibility of using THz waves to detect brain tumors by obtaining THz images using complex refractive index values

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