Abstract
Mepivacaine hydrochloride, 25 and 50mg/kg sc (with sacrifice at 15 min) produced higher (p < 0.005) drug levels in neonate (24-36-hr-old) rat brain and blood than in adult rat brain and blood; however, there was no significant difference in the brain-to-blood ratio of the drug between neonates and adults at either dose level. Intraarterial infusion of mepivacaine hydrochloride (20 μg/min) in adult rats resulted in measurable (GLC) mepivacaine base levels in pilocarpine-induced parotid salivary secretions collected throughout 30- and 45-min infusion periods. The saliva-to-blood ratios (±SEM) of mepivacaine base were 0.64 ± 0.13 after a 30-min infusion and 2.13 ± 0.48 after a 45-min infusion.
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