Abstract
Objective — We investigated the effect of age and coronary angioplasty on brain natriuretic peptide (BNP) and C-type natriuretic peptide (CNP).Methods and results — Serum levels of both peptides immediately before catheterization and at the end of angioplasty in 15 patients (age 68 ± 8 years, 8 men) with coronary artery disease (CAD) were compared to 12 elderly (65 ± 7 years, 8 men) and 16 non-elderly (34 ± 7 years, 10 men) healthy individuals.The results showed that in healthy individuals the levels of both peptides are age-dependent dissimilarly. Compared to the non-elderly, while BNP increases in the elderly (7.81 ± 1.60 vs. 10.01 ± 2.06 pg/ml, p = 0.002), CNP decreases (5.39 ± 1.30 vs. 2.22 ± 0.80 pg/ml, p < 0.001). On the other hand, compared to the elderly healthy persons, patients with CAD have a marked increase in the baseline levels of BNP (20.02 ± 17.43 pg/ml, p = 0.03) and CNP (4.41 ± 1.20 pg/ml, p < 0.001). However, both peptides remain stationary immediately after angioplasty (BNP, 21.02 ± 16.95; CNP, 4.51 ± 1.06 pg/ml ; both p = 0.4).Conclusions — BNP and CNP are differentially regulated by age in a healthy state, suggesting that each peptide has a distinct role during the aging process. The elevation of both peptides in CAD but little change shortly after angioplasty may indicate that both peptides respond to a chronic state rather than an acute episode of vascular damage.
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