Abstract
Introduction: Breast cancer (BC) is one of the most common cancers in women in developed countries. Approximately 15 to 20% of patients with BC have tumors with elevated levels of Human Epidermal Growth Factor Receptor 2 (HER2), which are associated with an aggressive clinical phenotype and poor prognosis. Brain metastases (BM) appears in more than 15% in the HER2-positive breast cancer population, which cause serious decrease in survival.
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