Abstract

Brain metastasis from cholangiocarcinoma (CCA) is a rare but fatal event. To the best of our knowledge, only few cases have been reported. Herein, we report the incident rate and a first case series of brain metastases from CCA. Between January 2006 and December 2010 5,164 patients were treated at Srinagarind hospital, Khon Kaen University; of those, 8 patients developed brain metastasis. Here we reviewed clinical data and survival times. The incident rate of brain metastases from CCA was 0.15%. The median age of the patients was 60 years. Tumor subtypes were intrahepatic in 6 and hilar in 2 patients. All suffered from symptoms related to brain metastasis. Three patients were treated with whole-brain radiation therapy (WBRT), one of whom also underwent surgery. The median survival after the diagnosis of brain metastasis was 9.5 weeks (1-28 weeks). The longest survival observed in a patient in RPA class I with two brain lesions and received WBRT. This is a first case series of brain metastases from CCA with the incident rate of 0.15%. It is rare and associated with short survival time.

Highlights

  • Cholangiocarcinoma (CCA), the bile duct epithelium neoplasm, has varied incidence and risk factors upon the region of the world (Jemal et al, 2011)

  • Between January 2006 and December 2010 5,164 patients were treated at Srinagarind hospital, Khon Kaen University; of those, 8 patients developed brain metastasis

  • We retrospectively reviewed all medical records of CCA patients with brain metastasis treated at Srinagarind hospital, Khon Kaen University between January 1, 2006 and December 31, 2010

Read more

Summary

Introduction

Cholangiocarcinoma (CCA), the bile duct epithelium neoplasm, has varied incidence and risk factors upon the region of the world (Jemal et al, 2011). The common metastatic sites of CCA are regional lymph nodes and adjacent organs. The previous reported distant metastatic sites of CCA are bone, muscle, and thyroid gland (Kidambi et al, 2011; Li et al, 2011; Park et al, 2012). Brain metastasis from CCA is extremely rare with a few case reports (Gudesblatt et al, 1984; Shuangshoti et al, 1989; Okamura et al, 2008; Mimatsu et al, 2011; William et al, 2011). We reported a series of brain metastatic CCA in our institution with the aim to provide useful information on this rare condition

Materials and Methods
Results
Discussion
Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call