Abstract
Objective: Wilson's disease (WD) is a genetic disorder with pathological copper accumulation in different organs with clinical symptoms related to damage of affected tissues (mainly hepatic or/and neurological). The advance of neurological disease in WD was usually assessed with physical examination. Currently the clinical scales like Unified Wilson's Disease rating Scale (UWDRS) or Global Assessment for WD(GAS) as well as brain magnetic resonance imaging (MRI) are proposed for it. The aim of these study was to determine whether brain MRI pathology in WD, scored in proposed MRI severity index, is associated with advance of neurological disease scored in UWDRS.
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