Abstract
The specific activity and the induction pattern of NAD- and NADP-linked isocitrate dehydrogenase (ICDH) of the brain of immature (6 weeks), mature (13 weeks), adult (33 weeks), and old (85 weeks) female rats were studied in an attempt to understand the mechanism of the aging process in relation to differential enzyme regulation. Ovarietctomy decreases the activity of all forms of ICDH in mature and adult rats but not in immature and old rats. Exogenous estradiol induces enzyme activity significantly in rats at all ages except in old rats. The magnitude of induction is higher in the mature rats. The stimulatory effect of estradiol is actinomycin sensitive.
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