Abstract
Aluminum doped brain homogenates have been proposed as a common set of standards to help resolve the disparity among the reported measured concentrations in plaques and tangled neurons in postmortem Alzheimer’s Disease brain specimens. Among the many analytical techniques utilized electron probe microanalysis (EPMA) alone provides both the capability to identify, by backscattered electron imaging, cells in unstained sections and to achieve, using wavelength dispersive x-ray spectrometry (WDS), a sensitivity for aluminum approaching the higher reported normal aged brain concentrations. We have prepared a set of freeze-dried 30 μm cryosections of aluminum doped homogenized rat brain. We report here the preliminary results of analysis by EPMA and briefly discuss some of the practical considerations in using such homogenates as a standard set for quantitation by WDS.
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Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
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