Abstract
The involvement of brain histamine in epileptogenesis has been studied in convulsive epilepsies [1], but not non-convulsive ones. As histamine controls the arousal maintenance, it possibly has a role in “paroxysmal loss of consciousness” (absence epilepsy) [2]. We have used the WAG/Rij rat strain as a model for absence epilepsy. This brain pathology manifests as spike-wave discharges (SWDs) in EEGs. Up to 95% of WAG/Rij rats display SWDs, mostly during passive awake or slow-wave sleep states. Minor behavioral changes, and unresponsiveness to external stimuli accompany SWDs [3, 4]. Additionally, about 30% of WAG/Rij rats show audiogenic convulsions, thus being a model for mixed epilepsy (absence epilepsy and audiogenic epilepsy).
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