Abstract
Individuals with mild cognitive impairment (MCI) have worse gait performance compared to cognitive healthy individuals (CHI). The discrepancy between imagined and performed timed up and go test (TUG), known as the TUG delta time, is a marker of brain gait control impairment in individuals with MCI. The study aims to examine the association between the TUG delta time and brain gray matter (GM) volumes in CHI and individuals with MCI. A total of 326 participants, 156 CHI and 170 MCI, with TUG delta time and a brain T1-weighted magnetic resonance imaging (MRI) were selected in this cross-sectional study. Individuals with MCI were older and had greater (i.e., worst performance) performed TUG and TUG delta time compared to CHI. The GM volume association with TUG delta time was examined in CHI and MCI assuming that increased TUG delta time would be associated with locally decreased GM volumes. No significant association was found in CHI, whereas TUG delta time was negatively associated with the GM volume of the right medial temporal lobe in individuals with MCI.
Highlights
Individuals with mild cognitive impairment (MCI) have worse gait performance compared to cognitive healthy individuals (CHI; Bahureksa et al, 2017; Beauchet et al, 2018)
The associations of brain gray matter (GM) volumes with TUG delta time are shown in Table 2 and Figure 1
No significant association at the cluster-corrected threshold was found in CHI, whereas TUG delta time was negatively associated with a large medial temporal cluster including the right entorhinal cortex, the amygdala, the parahippocampal gyrus, the insula, and the hippocampus (P ≤ 0.05 cluster-corrected) in individuals with MCI
Summary
Individuals with mild cognitive impairment (MCI) have worse gait performance compared to cognitive healthy individuals (CHI; Bahureksa et al, 2017; Beauchet et al, 2018). Impairment in gait control at a brain level explains in large part poor gait performance in individuals with MCI (Beauchet et al, 2018). It has been shown that individuals with MCI executed the imagined TUG more quickly than the performed TUG, but not CHI (Beauchet et al, 2014). The discrepancy between imagined and performed TUG, known as TUG delta time, has been proposed as a marker of impairment in gait control at a brain level in individuals with MCI (Beauchet et al, 2010, 2014).
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