Brain functional networks analysis of five fingers grasping in virtual reality environment.

Abstract

This study investigated the effects of different center of mass (COM) of the grasping device and visual time-delay on the information interaction between brain regions during five-finger grasping process. Nine healthy right-handed subjects used five fingers to grasp a special device in a virtual reality (VR) environment. Two independent variables were set in the experiment: the COM of the grasping device and the visual delay time. Place a 50 g mass randomly at five different directions of the grasping device base. The three levels of visual delay time appear randomly. The kinematics and dynamics and electroencephalogram (EEG) signals were recorded during the experiment. The brain network was constructed based on multiplex horizontal visibility graph (MHVG). Interlayer mutual information (MI) and phase locking value (PLV) were calculated to quantify the network, while clustering coefficient (C), shortest path length (L) and overall network efficiency (E) are selected to quantify the network characteristic. Statistical results show that when the mass is located in the radial side, during the load phase of grasping, the C and E is significantly higher than that in the proximal, ulnar and medial side, and L was significantly lower than that in the proximal and radial side. This shows that when grasping an object with a COM bias on the radial side, the process of brain feedforward control has higher level of information interaction and ability and it can build stronger sensorimotor memory. It is also found that the brain network features of theta, beta and gamma bands of EEG are positively correlated, especially between beta and gamma bands, which suggests there is a coupling relationship between different bands in information processing and transmission.Clinical Relevance- This study explains the neural mechanism of grasping control from the topological structure of the whole brain network level and the informatics.