Abstract
Background: Brain-derived neurotrophic factor (BDNF) is a crucial moderator of neuronal plasticity in adults, a potential association between BDNF and depression has been reported. Besides BDNF plays a role in glucose and energy metabolism. Methods: This work included 180 women (25-55 years old). Ninety diabetic patients with the clinical diagnosis of depression and 90 were normal controls. Plasma BDNF was evaluated using ELISA. The Zung Self‑Rating Depression Scale (SDS) consisting of 20 objects with a Likert‑type scale after each was used. HbA1c were measured in each patient using a clinical auto-analyzer. Results: BDNF levels in serum decreased significantly in diabetic depressed women compared to controls. Moreover, BDNF levels were inversely proportional to age, BMI, HbAc1 and LDL.Conclusion: The study suggests that age, BMI, HbAc1 have a definite impact on the circulating levels of BDNF in peripheral blood. The outcomes delineate that BDNF could participate in glucose impairment and lipid metabolism in diabetic patients.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
