Brain-derived neurotrophic factor and suicidal behavior in patients with posttraumatic stress disorder

Abstract

combined, the combined treatment is not likely to lead to full remission (100%). To assess an antidepressant’s efficacy, which was probably lower in the Sachs et al. study, the study’s design should have included a pure placebo arm. The study, however, followed the ethical principle of equipoise, which states that should be genuine uncertainty on the preferred treatment when designing interventional studies.