Abstract
Differences in symptomatology as a function of age at the time of brain damage have been observed for almost 200 years. The present contribution examines the use of young animals in research from the time of Julien Jean Cesar Legallois, who worked on rabbits and other animals in the early 1800s, to Margaret Kennard, who began her work on young primates in the mid‐1930s. Although the emphasis of this historical review is on experimental studies, some mention is made of parallel observations involving children in early clinical literature.
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