Abstract
Neuroscience A brain region called the lateral hypothalamic area is an integral node in the neurocircuitry controlling feeding behavior. In a mouse model of obesity, Rossi et al. found that a distinct class of neurons within this region acts as a brake on feeding, suppressing food intake (see the Perspective by Borgland). These neurons were potently and uniquely modified by diet-induced obesity. Thus, discrete populations of lateral hypothalamic area neurons are fundamental regulators of feeding behavior that might be targeted to treat eating disorders. Science , this issue p. [1271][1]; see also p. [1233][2] [1]: /lookup/doi/10.1126/science.aax1184 [2]: /lookup/doi/10.1126/science.aay0204
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