Abstract
1. 1. Catecholamine levels and turnover times were measured in several brain areas of two models of obese rats: ventromedial hypothalamic lesioned rats (VMH) and genetically obese rats (Fatty). 2. 2. Norepinephrine (NE) levels were increased only in the hypothalamus and in the remainder of the brain of Fatty rats. Dopamine (DA) levels were not modified. 3. 3. NE turnover time was accelerated in the medulla-oblongata-pons of VMH rats and in Fatty rats hypothalamus. DA turnover time was accelerated in the remainder of the brain of VMH rats while it was slowed in Fatty rats corpus striatum. 4. 4. These data are discussed in regard to the catecholamine hypothalamocentric hypothesis.
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