Abstract
Summary The binding of benzodiazepines to their specific brain receptors is affected by several drugs and behavioral changes. Four weeks of socio-environmental deprivation or isolation induces inter-male aggression not observable in grouped male mice. In addition, the number of benzodiazepine Type I receptors in synaptosomal membranes from isolated mice brains is significantly reduced in the cerebral cortex (40%), while Type II receptors were low in diencephalon (37%) and cerebellar cortex (28%). These results suggest that the isolation induced changes in the numbers of brain benzodiazepine receptors, mediating different effects of benzodiazepines (Type I = anxiolytic, anticonvulsant; Type II = sedation, ethanol potentiation), are responsible for some changes in benzodiazepine action in isolatedmice.
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