Abstract
Acute hypertension induced by various vasoactive substances can damage the blood-brain barrier (BBB) to protein in experimental animals. Thus, the brains from 27 out of 30 cats showed areas of extravasation of Evans blue-albumin after a systolic blood pressure increase exceeding 80 mm Hg induced by intravenous injection of metaraminol28. Similar lesions are seen in acute hypertension induced by angiotensin and noradrenaline. Approximately 70 per cent of rats developed BBB lesions after angiotension-provoked rise of the mean arterial blood pressure of 50–80 mm Hg 25 whereas a lower incidence has been reported in rabbits with the same vasoactive substance 6. The incidence of BBB lesions can be modified by several factors as will be discussed later. This might help to explain that some studies have failed to show permeability increase in acute hypertension (for a review of the literature see Johansson 197422.
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