Brain activity related to the ability to inhibit previous task sets: an fMRI study

Abstract

Switching between tasks requires individuals to inhibit mental representations of the previous task demands and to activate representations of the new demands. To date, investigators have identified only one way to measure task set inhibition-that is, through a backward inhibition (BI) paradigm. In this paradigm, participants take more time to return to a task set that was recently abandoned (e.g., "A" in an ABA task sequence) than to a nonrecently abandoned task set (e.g., CBA), and investigators have demonstrated that this time cost reflects time needed to overcome the inhibition of the recently abandoned task set. To date, however, investigators have not been able to use this paradigm, or any other, to isolate brain activity related to task set inhibition. For example, contrasting the brain activity elicited by ABA and CBA trials will not isolate activity related to task set inhibition, because inhibition occurs during the initial switch away from task A (i.e., ABA). Given that there is currently no way to directly isolate the brain activity related to task set inhibition, we decided instead to examine how brain activity during task switching varies in individuals who are better than others at inhibiting the previous task set. We found that participants who were good at inhibiting previous task sets, as measured with the BI paradigm, exhibited more activity in the basal ganglia and supplementary motor area/premotor area when task switching, as measured via functional magnetic resonance imaging. These findings suggest that activity in these regions plays a role in task set inhibition.