Brain activity and temporal coupling related to eye movements during REM sleep: EEG and MEG results

Abstract

EEG and MEG REM sleep gamma activity was studied immediately before rapid eye movement onset (PRE-EM), during REM sleep with eye movements away from eye movement onset –phasic-REM (Ph-REM) – and during REM sleep without eye movements, or tonic REM (T-REM). For this purpose, activity was segmented into three different time windows: of 62.5, 250 and 500 ms. Two strategies were used: one a statistical comparison of changes between T-REM, Ph-REM and PRE-EM; the other a descriptive approach using principal component analysis. Significant findings showed that both EEG and MEG gamma activity are higher directly before eye movement onset in PRE-EM periods and during Ph-REM than during T-REM; temporal coupling of electrical activity between the frontal and parietal regions is decreased, while temporal coupling between the right frontal and midline is increased. Just before eye movement onset, larger recording sites become related. For the first time, results showed a close temporal link between power and temporal coupling of fast oscillations andrapid eye movements in REM sleep, indicating increased activation, uncoupling between the left frontal executive areas and posterior sensory association regions and increased coupling between the right frontal attentional and midline alerting systems. Brain activity is reorganized by phasic events.