Abstract
Langerhans cell histiocytosis (LCH) is characterized by infiltrates of CD1a positive cells, similar to antigen presenting cells of the epidermis. Disease may be solitary or multifocal involving various anatomic sites including skin, mucosa, bone, lymph nodes, soft tissue, and organs. LCH occurs over a wide age range, yet is most commonly identified in the pediatric population. Historically, debate has focused on LCH as a neoplastic or reactive phenomenon. Willman and colleagues, in 1994, provided evidence that LCH was a clonal proliferation using the X-linked human androgen-receptor gene molecular assay.
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