Abstract
BRAF mutations play an important role in the classification and prognostication of low-grade gliomas and may offer a therapeutic target. We report a case of a V600E mutant low-grade glioma with morphological features of a ganglioglioma diagnosed in a 22-year-old female. Sections demonstrated a low-grade lesion with atypical astrocytic glial and neuronal elements, the latter stained positive for chromogranin A and BRAF V600E immunohistochemical stains; IDH-1 immunohistochemistry was negative. A provisional diagnosis of ganglioglioma (WHO grade I) was made with a differential diagnosis of pilocytic astrocytoma with gangliocytic differentiation.
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