Abstract
BrachyView is a novel in-body imaging system developed with the objective to provide real-time intraoperative dosimetry for low dose rate (LDR) prostate brachytherapy treatments. Seed positions can be reconstructed after implantation by the means of a high-resolution pinhole gamma camera. The obtained dataset is then combined with conventional trans-rectal ultrasound (TRUS) imaging to locate the effective source position within the prostate volume. This study presents a comparison of two data sets containing 96 and 98 I-25 brachytherapy sources and readout by two different pin-hole collimators with 800 µm and 500 µm, respectively. This study aims to assess the effect on reconstruction of large pinholes which allow for large Field of View (FoV) and statistics of counts on the seed’s projections. It was found that 100% of seeds were reconstructed by the means of the 500 µm collimator. Results from the 800 µm data showed that only 70% of seeds were reconstructed with a total 3D discrepancy of 8.20 mm in respect to CT data and an increased reconstructed position inaccuracy.
Highlights
Prostate cancer is a disease by which malignant cells form in the tissues of the prostate gland
This study aims to assess the effect on reconstruction of large pinholes which allow for large Field of View (FoV) and statistics of counts on the seed’s projections
Common treatments prescribed to patients include radical prostatectomy (RP), involving the removal of the entire prostate gland, external beam radiation therapy (EBRT) consisting in delivery of focused x-ray beams to the treatment area, and brachytherapy treatments, either consisting of low dose rate (LDR) or high dose rate (HDR) treatments [3]
Summary
Prostate cancer is a disease by which malignant cells form in the tissues of the prostate gland. Prostate cancer is quickly becoming the most common form of cancer across the globe. It is of grave importance that common treatment modalities available for prostate cancer treatment can be developed and improved in order to support patients and provide the best care possible. Common treatments prescribed to patients include radical prostatectomy (RP), involving the removal of the entire prostate gland, external beam radiation therapy (EBRT) consisting in delivery of focused x-ray beams to the treatment area, and brachytherapy treatments, either consisting of low dose rate (LDR) or high dose rate (HDR) treatments [3]. Radiation oncologists must carefully evaluate the patient in order to prescribe the most suitable treatment, some clinical measures for determination of patient selection for a treatment includes the grade of the tumour, Gleason score and prostate specific antigen scores (PSA) [4]
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