Abstract
Thirty-seven patients harboring recurrent malignant primary or metastatic brain tumors were treated by 40 implantations of high activity iodine-125 (125I) sources. All patients had been treated with radiation and most had been treated with chemotherapeutic agents, primarily nitrosoureas. Implantations were performed using computed tomography-directed stereotaxy; 125I sources were held in one or more afterloaded catheters that were removed after the desired dose (minimum tumor dose of 3,000–12,000 rad) had been delivered. Results of 34 implantation procedures are evaluable, and are discussed here.
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