B-PO03-147 OMEGA-3 POLYUNSATURATED FATTY ACIDS REDUCES POST-OPERATIVE ATRIAL FIBRILLATION IN PATIENTS UNDERGOING CARDIAC SURGERY

Abstract

Preoperative and post-operative omega-3 polyunsaturated fatty acids (PUFA) supplementation (both oral/enteral or parenteral) is an attractive therapeutic option for patients undergoing cardiac surgery surgery due to their anti-inflammatory and anti-arrhythmic properties. We aimed to demonstrate if PUFA supplementation prevents post-operative atrial fibrillation (POAF) in patients undergoing cardiac surgery. A systemic literature search was performed (until November 9, 2020) using PubMed, EMBASE, Web of Science, and Cochrane Central Register of Controlled Trials to identify trials (both randomized and prospective) evaluating PUFA supplementation post-cardiac surgery for POAF prevention. Mantel-Haenszel risk ratio (RR) with the Hartung-Knapp-Sidik-Jonkman random-effects model was used to summarize data between the two groups. Heterogeneity was assessed using I2 statistics. We included a total of 4,930 participants (2,270 in the PUFA group and 2,660 in the placebo group) enrolled in 22 clinical trials. Patients in the placebo group were older compared to the PFA group (64.9±2.80 vs 64.6±1.75 years). There was a significant reduction in the incidence of POAF in PUFA group as compared to the placebo (27.04% vs 36.20%, RR 0.69; 95% CI, 0.57-0.84; p<0.001, respectively). The test of heterogeneity (I2) was 56%. Number needed to treat was 11. Perioperative supplementation of n-3 polyunsaturated fatty acids significantly prevents the occurrence of postoperative atrial fibrillation in patients undergoing cardiac surgery.