BP.01.03] ASSOCIATION OF INTER-ARM BLOOD PRESSURE WITH AYSMPTOMATIC INTRACRANIAL AND EXTRACRANIAL ARTERIAL STENOSIS IN HYPERTENSION PATIENTS

Abstract

Objective: Inter-arm blood pressure (BP) difference has been associated with ischemic stroke. Local atherosclerosis of stroke differ among vulnerable individuals, whereas intracranial arterial stenosis (ICAS) is more frequently affected Asians, and extracranial arterial stenosis (ECAS) is more prevalent among whites.Design and method: We hereby sought to explore the association of inter-arm BP difference with ICAS and ECAS in stroke-free hypertensive patients in Chinese population. All the 885 subjects were evaluated for the presence and severity of ICAS and ECAS through computerized tomographic angiography. Both arm BP was measured simultaneously by the Vascular profiler 1000 device. Results: In the continuous study, ICAS was associated with age, male, average arm SBP, diabetes, anti-hypertensive treatment and inter-arm DBP difference. ECAS was associated with age, inter-arm SBP and LDL. In the categorical study, the subjects with the top quartile of inter-arm DBP difference (>4 mmHg) showed significantly higher risk of ICAS (OR = 2.038; 95% CI, 1.347∼4.177). The risk of ICAS in patients with inter-arm DBP difference >= 5 mmHg was 103% higher (P = 0.009). And the participants with the top quartile of inter-arm SBP difference (>6 mmHg) showed higher risk of ECAS (OR = 2.031; 95% CI, 1.195∼3.452). The risk of ECAS in patients with inter-arm SBP difference >= 10 mmHg was 225% higher. Conclusions: In conclusion, we here reported a diverse association of inter-arm SBP/DBP difference with the ICAS/ECAS. Inter-arm DBP difference might be the early symbol of ICAS in Chinese population, which need further verification in long-term cohort study.