Abstract
Previous studies have indicated that certain types of bovine cells preferentially respond to bovine interleukin-1 (IL-1) compared with IL-1 from other mammalian species. In this study, we demonstrate that bovine neutrophils undergo a substantially greater luminol-dependent chemiluminescence response to bovine IL-1 β than to human IL-1 α, human IL-1 β, or murine IL-1 α. Likewise, approximately 1000-fold less bovine IL-1 β than human IL-1 β was required to prime bovine neutrophils for an enhanced luminol-dependent chemiluminescence response to opsonized zymosan particles. A recombinant human IL-1 receptor antagonist was a potent inhibitor of bovine neutrophil stimulation and priming by homologous and heterologous IL-1. These data indicate a hierarchy amongst members of the IL-1 family in terms of their relative abilities to modulate the functional activation of bovine neutrophils.
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