Abstract
The application of gene therapy for malignant gliomas is still under study and the use of specific vectors represents an important contribution. Here, we investigated bovine herpesvirus 4 (BoHV-4), which is non-pathogenic if injected into the rodent brain. We show that the vector can infect mouse, rat and human glioma cell lines and primary cultures obtained from human glioblastoma in vitro. BoHV-4 was injected into a tumour grown in rat brain. Although virus expression was scattered across the tumour mass, it was mainly located in the peripheral area of larger gliomas. These data support BoHV-4 as a candidate vector for glioma treatment.
Highlights
The application of gene therapy for malignant gliomas is still under study and the use of specific vectors represents an important contribution
In thirteen studies that performed clinical trials with gene therapy, results showed an increase in mean survival time ranging from 8.9 months to 14.4 months [1]
The optimization of potential vectors is essential for clinical effectiveness of cancer gene therapy
Summary
The application of gene therapy for malignant gliomas is still under study and the use of specific vectors represents an important contribution. BoHV-4 does not replicate in mouse or rat brain, but reporter gene expression has been shown in ependymal cells and the rostral migratory stream (RMS)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
