Bovine Colostrum Supplementation During Running Training Increases Intestinal Permeability

Jonathan D Buckley,Ross N Butler,Grant D Brinkworth,Emma Southcott

doi:10.3390/nu1020224

Abstract

Endurance exercise training can increase intestinal permeability which may contribute to the development of gastrointestinal symptoms in some athletes. Bovine colostrum (BC) supplementation reduces intestinal permeability induced by non-steroidal anti-inflammatory drugs. This study aimed to determine whether BC could also reduce intestinal permeability induced by endurance exercise. Thirty healthy adult males (25.0 ± 4.7 yr; mean ± SD) completed eight weeks of running three times per week for 45 minutes at their lactate threshold while consuming 60 g/day of BC, whey protein (WP) or control (CON). Intestinal permeability was assessed at baseline and after eight weeks by measuring the ratio of urinary lactulose (L) and rhamnose (R) excretion. After eight weeks the L/R ratio increased significantly more in volunteers consuming BC (251 ± 140%) compared with WP (21 ± 35%, P < 0.05) and CON (−7 ± 13%, P < 0.02). The increase in intestinal permeability with BC may have been due to BC inducing greater leakiness of tight junctions between enterocytes or by increasing macromolecular transport as it does in neonatal gut. Further research should investigate the potential for BC to increase intestinal macromolecular transport in adults.

Highlights

Supplementation with bovine colostrum (BC) during athletic training improves exercise performance for both endurance [1] and anaerobic [2,3] activities
Endurance exercise can increase the permeability of the intestinal barrier [7,8] and this might contribute to some of the gastrointestinal symptoms that are evident in endurance athletes after prolonged exercise [9]
Given that BC is a supplement consumed by endurance athletes to improve performance and recovery, we hypothesized that it might reduce the intestinal permeability that can be induced through the performance of endurance exercise, and potentially protect against the development of endurance exercise-induced gastrointestinal disturbances

Summary

Introduction

Supplementation with bovine colostrum (BC) during athletic training improves exercise performance for both endurance [1] and anaerobic [2,3] activities. BC has been shown to improve recovery [4] and buffer capacity during exercise [5], as well as increasing resistance to upper respiratory tract infection [6]. Endurance exercise can increase the permeability of the intestinal barrier [7,8] and this might contribute to some of the gastrointestinal symptoms that are evident in endurance athletes after prolonged exercise [9]. Given that BC is a supplement consumed by endurance athletes to improve performance and recovery, we hypothesized that it might reduce the intestinal permeability that can be induced through the performance of endurance exercise, and potentially protect against the development of endurance exercise-induced gastrointestinal disturbances

Objectives

Methods

Results