Abstract
A thyroglobulin-like protein with a sedimentation constant of 36.6S has been isolated from bovine thyroid glands and further characterized. Its molecular weight, 2 × 10 6, is close to three times that of 19S thyroglobulin, the major thyroid iodoprotein. The amino acid composition of this iodoprotein also closely resembled that of 19S thyroglobulin and of the 27S iodoprotein. A reaction of identity in a double diffusion system with 19S, 27S and 36.6S has also been found. The iodine content of the 36.6S iodoprotein was greater than that of 19S thyroglobulin, but similar to that of the 27S species isolated from the same thyroid extract.
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