Abstract
Ultrasound contrast agents are gas core micron size bubbles coated with a layer of lipids/proteins to stabilize them against premature dissolution in the bloodstream. In addition to enhancing the contrast of the image, contrast agents have been implicated in numerous harmful and beneficial bioeffects. In the present study, ultrasound excited collapse of a coated microbubble near a plane has been studied using an axisymmetric Boundary Element method. The coating of the microbubble is modeled as a viscoelastic interface using an in-house developed strain-softening model (exponential elasticity model). The influence of the shell model on the stability of the numerical simulation during the microbubble jet formation has been investigated. The numerical approach was compared and validated with earlier studies. The effects of ultrasound excitation parameters and mechanical properties of the coating, i.e., shell viscosity and elasticity, on the bubble behaviors and the velocity and pressure in the surrounding fluid have been studied.
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