Abstract
Three-D head geometrical models of eight healthy subjects and 11 hydrocephalus patients were built using their CINE phase-contrast MRI data and used for computer simulations under three different inlet/outlet boundary conditions (BCs). The maximum cerebrospinal fluid (CSF) pressure and the ventricular system volume were more effective and accurate than the other parameters in evaluating the patients’ conditions. In constant CSF pressure, the computational patient models were 18.5% more sensitive to CSF volume changes in the ventricular system under BC “C”. Pulsatile CSF flow rate diagrams were used for inlet and outlet BCs of BC “C”. BC “C” was suggested to evaluate the intracranial compliance of the hydrocephalus patients. The results suggested using the computational fluid dynamic (CFD) method and the fully coupled fluid-structure interaction (FSI) method for the CSF dynamic analysis in patients with external and internal hydrocephalus, respectively.
Highlights
Three-D head geometrical models of eight healthy subjects and 11 hydrocephalus patients were built using their CINE phase-contrast MRI data and used for computer simulations under three different inlet/outlet boundary conditions (BCs)
The results showed that the difference between the experimental and computer-simulated values of the maximum cerebrospinal fluid (CSF) pressure in subarachnoid space (SAS) in patient No 1–10 was
The inlet/outlet BCs were defined in terms of the CSF pressure and CSF flow rate based on the previous studies and in vivo examinations
Summary
Three-D head geometrical models of eight healthy subjects and 11 hydrocephalus patients were built using their CINE phase-contrast MRI data and used for computer simulations under three different inlet/outlet boundary conditions (BCs). The maximum cerebrospinal fluid (CSF) pressure and the ventricular system volume were more effective and accurate than the other parameters in evaluating the patients’ conditions. In constant CSF pressure, the computational patient models were 18.5% more sensitive to CSF volume changes in the ventricular system under BC “C”. 1234567890():,; Cerebrospinal fluid (CSF) acts as a medium for transporting nutrients and neuroendocrine substances and removing toxic metabolites. Experimental methods have limitations in measuring parameters affecting the disease[5,6] They are insufficiently accurate in measuring biomechanical loadings and local flow patterns[7]. The study of BCs in hydrocephalus modeling includes evaluating changes in both essential BCs (e.g., non-slip-boundary conditions) and natural BCs (e.g., pressure/load). This study mainly aimed to evaluate the effects of natural BC changes on the computational biomechanics of hydrocephalus
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