Abstract
The aim of the study is mainly to study the subject of BoNT-A injection to improve IAH in rats undergoing abdominal angioplasty. The study problem in surgery, especially in ICU, burn, and trauma centers, intra-abdominal hypertension (IAH), and abdominal compartment syndrome (ACS) are common complications. At present, there are various treatments for IAH. The intramuscular injection of Botulinum toxin type A (BoNT-A) into the abdominal wall has received a lot of attention. Based on this, this study proposes a method for measuring abdominal pressure, applies BoNT-A to reduce abdominal pressure in the IAH state of abdominal wall angioplasty, and explores a way to increase the compliance of the abdominal wall under the premise of maintaining the sealing of the abdominal cavity, so as to realize the expansion of the abdominal cavity. A method is achieved to reduce intra-abdominal pressure and eliminate or alleviate ACS. The results of the experiment showed that when the rats in the control group were injected with the same amount of normal saline as the rats in the experimental group, the IAP was significantly higher than that in the experimental group (P < 0.05). This shows that BoNT-A increases the compliance of the abdominal wall while maintaining the closure of the abdominal cavity, thereby increasing the volume of the abdominal cavity and alleviating the state of IAH in rats.
Highlights
In recent years, due to the gradual increase in mortality of abdominal compartment syndrome (ACS) and intra-abdominal hypertension (IAH), effective treatment of them has attracted increasing attention [1, 2]
The overactivity of the whole body joints caused by Noonan syndrome leads to children’s trapezius spasm and causes neck pain and craniocervical headaches; Tofts LJ studied the effect of Botulinum toxin type A (BoNT-A) on its treatment [6]; Bittar studied the efficacy of BoNT-A in the treatment of postherpetic neuralgia [7]; Park studied the effect of Botox type A through the JNK signaling pathway that inhibits the pro-fibrosis effect of hypertrophic scar fibroblasts [8]
Different doses of BoNT-A were set in the control and experimental groups to evaluate the effect of BoNT-A on decreasing abdominal pressure in the IAH state of abdominal wall angioplasty
Summary
Due to the gradual increase in mortality of ACS and IAH, effective treatment of them has attracted increasing attention [1, 2]. Erefore, exploring BoNT-A injection to improve IAH in rats undergoing abdominal angioplasty has important research significance. It can be seen that there are few studies on the effect of BoNT-A on IAH in rats. BoNT-A injection is used to improve IAH in rats undergoing abdominal angioplasty. E study contribution takes IAH as the research object to study the mechanism of BoNT-A on improving IAH in rats undergoing abdominal wall angioplasty. Different doses of BoNT-A were set in the control and experimental groups to evaluate the effect of BoNT-A on decreasing abdominal pressure in the IAH state of abdominal wall angioplasty. BoNT-A can increase abdominal wall compliance while preserving abdominal cavity closure and reduce IAH in rats, according to the results of the experiments. Is study found that injecting BoNT-A into the abdominal wall muscles of rats increased the abdominal. Computational Intelligence and Neuroscience cavity’s volume and decreased its pressure, providing BoNTA for the clinical treatment of abdominal compartment syndrome A reliable basis
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