Botulinum toxin type A affects cell cycle distribution of fibroblasts derived from hypertrophic scar

Abstract

Clinical observations indicate that botbulinum toxin type A (BTXA) can improve the eventual appearance of hypertrophic scar and inhibit the growth of hypertrophic scar. 1 lger G. Anthoy E. Brisse T. et al. Botulinum toxin to improve facial wound healing: a prospective, blinded, placebo-controlled study. Mayo Clin Proc. 2006; 81: 1023-1028 Google Scholar , 2 Zimbler M.S. Holds J.B. Kokoska M.S. et al. Effect of botulinum toxin pretreatment on laser resurfacing results: a prospective, randomized, blinded trial. Arch Facial Plast Surg. 2001; 3: 165-169 Google Scholar , 3 Tollefson T.T. Senders C.M. Sykes J.M. et al. Botulinum toxin to improve results in cleft lip repair. Arch Facial Plast Surg. 2006; 8: 221-222 Google Scholar , 4 David A. Sherris M. Holger G. et al. Botulinum toxin to minimize facial scarring. Facial Plast Surg. 2002; 18: 35-39 Google Scholar But, the mechanism of which is unknown,aparted from the viewpoints that BTXA improves hypertrophic scar by decreasing tensile force during the course of traumatic cicatrisation. The aim of this study was to explore the molecular mechanism that may partly explain the above clinical phenomenon.This study will provide a theoretical base, experimental data and widely applicable strategy for therapeutic enhancement of hypertrophic scar.