Abstract
BackgroundThe purpose of this study was to evaluate the effects of botulinum toxin A (BTX) injection into the anterior belly of the digastric muscle on a growing rat.MethodsTen Sprague Dawley rats were used in this study. When the rats were 13 days old, 0.5 units of BTX was injected into the anterior belly of the digastric muscle for the experimental group (n = 5). For the control, the same volume of normal saline was injected (n = 5). The rats were sacrificed at 60 days old, and the skulls were harvested for micro-computed tomography (μCT) analysis.ResultsIn anthropometric analysis, the zygomatic arch and mandibular bi-condylar width were significantly lower in the experimental group than those in the control group (P = 0.025 and 0.027, respectively). The maxillary point width was significantly higher in the experimental group than that in the control group (P = 0.020).ConclusionBTX injection into the anterior belly of the digastric muscle had effects on the maxillofacial bony width in growing rats.
Highlights
The purpose of this study was to evaluate the effects of botulinum toxin A (BTX) injection into the anterior belly of the digastric muscle on a growing rat
As the dental arch is positioned in the balanced line between the buccinator and tongue muscles, control of muscle power will be beneficial during orthodontic treatment [6]
When the rats were 13 days old, 0.5 unit of BTX was injected into the anterior belly of the digastric muscle of the experimental group (n = 5), and 0.5 ml of normal saline (0.9% sodium chloride) was injected into the same muscle in the control group (n = 5)
Summary
The purpose of this study was to evaluate the effects of botulinum toxin A (BTX) injection into the anterior belly of the digastric muscle on a growing rat. Botulinum toxin A (BTX) paralyzes the muscle and has been used for therapeutic purposes [1]. BTX injection is considered a cosmetic therapy and it has been used for the removal of wrinkles or the reduction of muscle volume [2]. The indication for BTX injection has become much wider [1, 3]. BTX injection into the maxillofacial area has been used for the treatment of orofacial pain [4], as well as for the prevention of open bite [4] or plate fracture [5]. Orthodontic treatment can be classified as adult orthodontics and child orthodontics.
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