Abstract

Prior transfection with antisense oligonucleotides to the H13 and 4F2 hc genes, singly or in combination, was found to inhibit phytohaemagglutinin-induced activation of cationic amino-acid transport system y + in human peripheral blood mononuclear cells (mostly circulating lymphocytes). These effects on system y + function or expression mean that 4F2 hc cannot only be the molecular basis of system y +L.

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