Abstract
Both Ethanol and Ethyl Acetate Curcuma Zedoaraia Extract was Capable of Inducing Cells Death in T47D Cell Line Culture
Highlights
Curcuma zedoaria (CZ) has been proven capable of inducing apoptosis in cells cancer
In this study 21 wells were assign into seven groups: control group (T47D); treatment groups consisting of group of ethanol CZ extract 46 (EtZ-46); group of ethanol CZ extract 23 (EtZ-23); group of ethanol CZ extract 11 (EtZ-11); and group of ethyl acetate CZ extract 111 (AcZ-111); group of ethyl acetate CZ extract 55 (AcZ-55); and group of ethyl acetate CZ extract 27 (AcZ-27)
The highest number of apoptosis cells was in AcZ-111, followed by AcZ-55, EtZ-46, EtZ-23, EtZ-23, T47D, and the lowest was in AcZ-27
Summary
Curcuma zedoaria (CZ) has been proven capable of inducing apoptosis in cells cancer. CZ extraction can be performed by ethanol and acetyl acetate as solvent. In 2018, the number of breast cancer related death was 627.000 or around 15% of all cancer death.[1,2] Albeit, the incidence of BC was higher in developed countries, its percentage is increasing in almost each region globally.[1] In US, for instance, new invasive case of BC was estimated to be 268.600 in 2019, and approximately 41.760 (15.5%) of them are expected to die.[3] Likewise, in Asia, there were increasing new cases of BC among women in Pakistan, China, India, and Thailand during 19902015.4 from 1989 to 2017, the mortality rate of BC has reduced significantly about 40%, resulting in 375.900 BC death can be averted.[3] The decrease in BC mortality rate was attributable to screening program, improvement of treatment, earlier detection, and adjuvant therapy originate from botanical product.[3,5,6] Curcuma zedoaria (CZ) is a botanical product has been proven capable of inducing apoptosis on various cells such as Daltons Lymphoma Ascites (DLAs), Lung Carcinoma (A549), nasopharyngeal carcinoma (KB), leukemic (K562), and T47D cell lines.[6,7] My own study that have been published indicated that the potential effect of water extract of CZ on T47D cells apoptosis remains low, less than 10%.6. The decrease in BC mortality rate was attributable to screening program, improvement of treatment, earlier detection, and adjuvant therapy originate from botanical product.[3,5,6] Curcuma zedoaria (CZ) is a botanical product has been proven capable of inducing apoptosis on various cells such as Daltons Lymphoma Ascites (DLAs), Lung Carcinoma (A549), nasopharyngeal carcinoma (KB), leukemic (K562), and T47D cell lines.[6,7] My own study that have been published indicated that the potential effect of water extract of CZ on T47D cells apoptosis remains low, less than 10%.6 On the other hand, some evidences showed that both ethanol and ethyl acetate CZ extract has been proven capable of inducing apoptosis on various cancer cells.[6,7,8] the potential effect of ethanol and ethyl acetate CZ extract which one is more effective on T47D cells apoptosis remain unclear
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