Boswellia&nbsp;serrata Extract as an Antibiofilm Agent against Candida spp.

Petr Jaroš,Maria Vrublevskaya,Irena Kolouchová,Kateřina Demnerová,Kristýna Lokočová,Jana Michailidu

doi:10.3390/microorganisms10010171

Boswellia serrata Extract as an Antibiofilm Agent against Candida spp.

Petr Jaroš, Maria Vrublevskaya + Show 4 more

Open Access

https://doi.org/10.3390/microorganisms10010171

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Journal: Microorganisms	Publication Date: Jan 13, 2022
Citations: 3	License type: CC BY 4.0

Affiliation: University of Chemistry and Technology

Abstract

The use of antibiotics or antifungals to control infections caused by pathogenic microorganisms is currently insufficiently effective because of their emerging resistance. Thanks to the ability of microorganisms to form a biofilm and thus increase their resistance to administered drugs even more, modern medicine faces the task of finding novel substances to combat infections caused by them. In this regard, the effects of essential oils or plant extracts are often studied. Among the relatively neglected plants is Boswellia serrata, which has a high content of biologically active boswellic acids. In this study, we focused on one of the most common nosocomial infections, which are caused by Candida species. The most common representative is C. albicans, although the number of infections caused by non-albicans species has recently been increasing. We focused on the antifungal activity of Boswellia serrata extract Bioswellix against planktonic and adhering cells of Candida albicans, Candida parapsilosis and Candida krusei. The antifungal activity against adhering cells was further explored by determining the metabolic activity of cells (MTT) and determining the total amount of biofilm using crystal violet. Boswellic acid-containing plant extract was shown to suppress the growth of a suspension population of all tested Candida species. Boswellia serrata extract Bioswellix was most effective in inhibiting C. albicans biofilm formation.

Highlights

Many diseases caused by pathogenic and opportunistic pathogens are very difficult to treat with conventionally used drugs, antibiotics or antifungals, mainly due to the ability of microorganisms to form a biofilm and gain greater resistance to drugs [1]
Our study addressed the antimicrobial effect of Boswellia serrata extract Bioswellix and its influence on the formation and stability of the biofilm of Candida albicans ATCC 2091, Candida krusei CCM 8271 and Candida parapsilosis CCM 8260
Pathogenic and pathogenic microorganisms have long posed a major threat to humanity because they cause a variety of diseases

Summary

Introduction

Many diseases caused by pathogenic and opportunistic pathogens are very difficult to treat with conventionally used drugs, antibiotics or antifungals, mainly due to the ability of microorganisms to form a biofilm and gain greater resistance to drugs [1]. Medical disciplines are not the only area where the occurrence of biofilms poses significant problems and complications [2]. We can often encounter the use of a variety of chemicals and detergents to remove the biofilm, such as hydroxides [5] or using new natural biologically active substances such as alkaloids, coumarins, saponins, tannins, quinones [6], phenols [7] and others. Natural agents include boswellic acids, which are present in the resins of Boswellia serata and belong to a large group of biologically active pentacyclic triterpenes [6]. Boswellic acids have significant activity against a number of inflammatory diseases, such as cancer, arthritis, chronic colitis, ulcerative colitis, Crohn’s disease and bronchial asthma [8,9]

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