Abstract
Boswellia carterii Birdwood Topical Microemulsion for the Treatment of Inflammatory Dermatological Conditions; a Prospective Study
Highlights
Skin inflammatory diseases arise generally from chemical, physical or microbial insults.1Acne is a disease that affects the pilosebaceous follicles which consist of the sebaceous glands connected functionally and anatomically to the hair follicles
Acne results from the combination of different factors; excessive production of sebum as a result of stimulation of the sebaceous glands by endogenous androgens; obstruction of the exit of the sebaceous follicles due to excess keratinocytes production; hyperactivity of Propionibacterium acnes which is normal flora living in the pilosebaceous unit; and inflammation triggered by sebum released into the surrounding areas of the skin.[2]
Several studies reported the activation of NF-κB, a transcription factor essential for the expression of proinflammatory cytokine genes in acne lesions,[17] where the levels of TNFα, IL-1β, IL8 and IL-10 were shown to be significantly higher in skin involved in acne lesions compared to uninvolved skin
Summary
Skin inflammatory diseases arise generally from chemical, physical or microbial insults.1Acne is a disease that affects the pilosebaceous follicles which consist of the sebaceous glands connected functionally and anatomically to the hair follicles. Acne results from the combination of different factors; excessive production of sebum as a result of stimulation of the sebaceous glands by endogenous androgens; obstruction of the exit of the sebaceous follicles due to excess keratinocytes production; hyperactivity of Propionibacterium acnes which is normal flora living in the pilosebaceous unit; and inflammation triggered by sebum released into the surrounding areas of the skin.[2] The early stage of acne is a non-inflammatory process. It involves a number of open and closed comedones.
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