Bosentan treatment for pulmonary arterial hypertension due to patent ductus arteriosus and Down's syndrome in an infant

Abstract

Down's syndrome is the most common autosomal chromosome abnormality with an estimated incidence of approximately 1.1 per 1000 births [ [1] Morris J.K. Alberman E. Trends in Down's syndrome live births and antenatal diagnoses in England and Wales from 1989 to 2008: analysis of data from the National Down Syndrome Cytogenetic Register. BMJ. 2009; 339 Google Scholar ]. The prevalence of congenital heart disease (CHD) in the Down's population is 40–60% [ 2 D'Alto M. Romeo E. Argiento P. et al. Therapy for pulmonary arterial hypertension due to congenital heart disease and Down's syndrome. Int J Cardiol. 2013; 164: 323-326 Abstract Full Text Full Text PDF PubMed Scopus (39) Google Scholar , 3 Suzuki K. Yamaki S. Mimori S. et al. Pulmonary vascular disease in Down's syndrome with complete atrioventricular septal defect. Am J Cardiol. 2000; 86: 434-437 Abstract Full Text Full Text PDF PubMed Scopus (59) Google Scholar , 4 Rowe R.D. Uchida I.A. Cardiac malformation in mongolism: a prospective study of 184 mongoloid children. Am J Med. 1961; 31: 726-735 Abstract Full Text PDF PubMed Scopus (134) Google Scholar ] and patent ductus arteriosus (PDA) is a common congenital heart disease and makes up 5–10% of all heart disease in newborns at term [ 5 Yunfei L. Ke L. Qi A. et al. Transcatheter intervention following ambrisentan treatment in an adult patient with patent ductus arteriosus and severe pulmonary hypertension. Int J Cardiol. 2014; 173 (e16–7) Abstract Full Text Full Text PDF PubMed Scopus (6) Google Scholar , 6 Mitchell S.C. Korones S.B. Berendes H.W. Congenital heart disease in 56,109 births. Incidence and natural history. Circulation. 1971; 43: 323-332 Crossref PubMed Scopus (934) Google Scholar ]. Children with Down's syndrome may develop progressive pulmonary changes earlier than non-Down's counter-parts with similar congenital heart defects and harder to decrease the pressure [ [7] Soudon P. Stijns M. Tremouroux-Wattiez M. et al. Precocity of pulmonary vascular obstruction of Down's syndrome. Eur J Cardiol. 1975; 2: 473-476 PubMed Google Scholar ]. Here we are going to report an infant with pulmonary arterial hypertension due to patent ductus arteriosus and Down's syndrome.