Abstract
Boronic esters are investigated as a pathway to conjugate biological molecules to polymers. Although the stability of the boronic ester was slightly dependent on the molecular weight of the polymer and the pH value, the conjugates were stable when micelles were endocytosed by cells. Only the onset of apoptosis led to cleavage of the boronic ester.
Highlights
Boronic esters are investigated as a pathway to conjugate biological molecules to polymers
The stability of the boronic ester was slightly dependent on the molecular weight of the polymer and the pH value, the conjugates were stable when micelles were endocytosed by cells
The common feature of these reactions is the formation of permanent linkers disulfides, which are the result of the reaction between pyridyl disulfide (PDS) and thiols, can be cleaved under reductive conditions
Summary
Boronic esters are investigated as a pathway to conjugate biological molecules to polymers. The stability of the boronic ester was slightly dependent on the molecular weight of the polymer and the pH value, the conjugates were stable when micelles were endocytosed by cells.
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