Abstract
In recent years, glucose-sensitive drug delivery systems have attracted considerable attention in the treatment of diabetes. These systems can regulate payload release by the changes of blood glucose levels continuously and automatically with potential application in self-regulated drug delivery. Boronic acid (BA), especially phenylboronic acid (PBA), as glucose-sensitive agent has been the focus of research in the design of glucose-sensitive platforms. This article reviews the previous attempts at the developments of PBA-based glucose-sensitive drug delivery systems regarding the PBA-functionalized materials and glucose-triggered drug delivery. The obstacles and potential developments of glucose-sensitive drug delivery systems based on PBA for diabetes treatment in the future are also described. The PBA-functionalized platforms that regulate drug delivery induced by glucose are expected to contribute significantly to the design and development of advanced intelligent self-regulated drug delivery systems for treatment of diabetes.
Highlights
Diabetes, a human disorder of glucose metabolism, has been one of the globally leading causes of death with a sharply increasing number of patients
There are great developments in the developments in the glucose-sensitive carriers based on phenylboronic acid (PBA) for self-regulated drug delivery
We have reviewed the recent developments in glucose-sensitive drug delivery systems based on PBA
Summary
A human disorder of glucose metabolism, has been one of the globally leading causes of death with a sharply increasing number of patients. Great efforts have been devoted to investigating self-regulated insulin delivery systems, which would be a promising alternative to control the diabetic blood glucose levels. Three kinds of glucose-sensitive materials, based on boronic acid (BA, phenylboronic acid (PBA)), glucose oxidase (GOD), and concanavalin A (Con A), have attracted growing attention, which are utilized in self-regulated insulin delivery systems [2,3,4,5,6]. Hydrophilicity lays the foundation for the glucose-sensitivity of PBA-functionalized materials. One kind one of cis-diol is well-documented to form stable glucose-PBA complexcomplex at neutral. The increase of hydrophilicity of PBA-containing carriers neutral or alkaline pH. The increase of hydrophilicity of PBA-containing carriers provides provides the the swelling swelling or or disassembling disassembling of of the the drug drug delivery delivery vehicles, vehicles, resulting resulting in in glucose-triggered glucose-triggered drug release
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