Abstract
A reversible boronate-diol interaction provides a versatile synthetic platform for molecular recognitions whose binding specificity can be molecularly tailored. We found that boronate derivatives with relatively strong acidity generally undergo a diphosphate-specific recognition among other phosphates under weakly acidic pH conditions, a feature relevant to DNA sequencing. (11)B and (31)P NMR studies identified "tetrahedral boronate and divalent diphosphate" as a pair responsible for forming a 1:1 stoichiometric complex, which manifests as a unique pH-dependent stability.
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