Abstract
BackgroundBorderline Brenner tumor of the ovary is a rare entity characterized by papillary structures with a fibro-vascular core, covered by a transitional epithelium, and by the absence of stromal infiltration. It is associated, by definition, with a benign component of Brenner tumor.CaseWe report a case of a 68-year-old woman, with a right ovarian mass, whose morphology and immuno-profile were consistent with the diagnosis of a borderline Brenner tumor. Immunohistochemistry carried out on selected markers may help to formulate the diagnosis, more than the molecular analyses.
Highlights
Borderline Brenner tumor of the ovary is a rare entity characterized by papillary structures with a fibro-vascular core, covered by a transitional epithelium, and by the absence of stromal infiltration
Borderline Brenner tumors, usually associated with a benign Brenner tumor, are characterized by papillary structures with a fibro-vascular core covered by a transitional epithelium
We report the case of a 68-year-old woman with a right ovarian mass, for which the morphology and immunohistochemistry (IHC) analyses were consistent with the diagnosis of borderline Brenner tumor
Summary
Transitional cell tumors of the ovary, described for the first time by Brenner in 1907, are rare neoplasms and account for about 2% of all ovarian tumors. We report the case of a 68-year-old woman with a right ovarian mass, for which the morphology and immunohistochemistry (IHC) analyses were consistent with the diagnosis of borderline Brenner tumor. In order to find p16 promoter hyper-methylation, molecular analysis was carried out using a commercial kit Figure 2 Gross and microscopic description of Brenner tumor: a) Ovarian mass with solid papillary component; b) H & E representative of a solid adeno-fibromatous component (5X); c) H & E representative of cystic formations lined by mucinous columnar epithelium and by papillary transitional cellular component (10X); d) H & E representative of transitional epithelial cells with pale cytoplasm, indented nuclei and mild nuclear atypia (40X). Morphology and immuno-profile of the sample were consistent with the diagnosis of a borderline Brenner tumor of the ovary
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