Borate Bioglass Based Drug Delivery of Teicoplanin for Treating Osteomyelitis

Abstract

A drug delivery system which contains antibiotics for treating osteomyelitis based on a borate bioactive glass was developed.The system was consisted of the borate bioactive glass(6Na2O-8K2O-8MgO-22CaO-54B2O3-2P2O5,mol%) as the solid phase,the solution of chitosan,critic acid and glucose as the liquid phase and carried water-soluble teicoplanin as the antibiotics.In vitro test,the drug release behavior,the mechanical properties and the biocompatibility of the drug delivery system were investigated,when the drug delivery device was immersed in phosphate buffer solution(PBS).The drug concentration in PBS were tested by HPLC(High Performance Liquid Chromatography).The drug releasing process could last as long as 30d and 72% of the drug content was released within the first week.The mechanism for the drug releasing from the devices was in accordance with Fick's diffusion law,when the process was simulated in the Peppas model.The XRD results proved that the bioactive glass material converted into hydroapatite(HA) during the drug release process,indicating that the system had bioactivity in vitro.In vivo test on rabbits,the drug delivery system cured the osteomyelitis in tibial bone,and stimulated the regeneration of tibial bone.The above results proved that the borate bioactive glass was a suitable material for carrying antibiotics to cure osteomyelitis,and for stimulating bone regeneration.