Abstract
In the areas of catalysis and organic chemistry, the development of versatile and efficient catalytic systems has long been a challenge, primarily due to the intricate relationship between ligands and transition metal centers. This study addresses this challenge by exploring the concept of ligand synergy to enhance the generality of catalytic systems, a crucial metric for their practical utility. By combining N-heterocyclic carbene (NHC) and phosphine ligands, we unveil a novel catalytic system that exhibits high level of generality in the Buchwald-Hartwig cross-coupling reaction. Our findings not only demonstrate the enhanced efficiency of this system, leading to the synthesis of valuable compounds with applications in organic electroluminescent devices and the pharmaceutical industry, but also shed light on the broader potential of ligand synergy in catalysis. Through machine learning analysis, we uncover the critical role of specific ligand properties, further paving the way for rational catalyst design.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
